BOSENTAN FOR DUMMIES

Bosentan is surely an inducer of CYP3A and CYP2C9. For that reason plasma concentrations of medicines metabolized by these two isozymes will probably be lessened when bosentan is coadministered.Bosentan is a particular and competitive antagonist at endothelin receptor sorts ETA and ETB. Bosentan has a rather greater affinity for ETA receptors than